Metformin And Menopause | Does Metformin Affect Menopause

Summary: Metformin, a commonly used medication to treat type 2 diabetes, has recently gained popularity as a possible treatment for some symptoms of menopause. Here are five important aspects to know about using metformin during menopause.

1. How Metformin Works

Metformin works by decreasing the amount of glucose (sugar) produced by the liver and also reducing how much glucose is absorbed by the intestines. This leads to lower blood sugar levels, which can be beneficial in treating diabetes. However, researchers believe that metformin may also help decrease the severity of several symptoms associated with menopause.

In addition, metformin has been found to improve insulin sensitivity and lower insulin levels in the blood, which could help alleviate some hormone-related symptoms of menopause.

While metformin is not a hormone replacement therapy (HRT), some studies suggest that it may have similar effects on hormones, such as lowering androgen levels.

2. Effect on Weight and Body Composition

Menopause often leads to weight gain and changes in body composition, particularly in the abdominal area. Several studies have shown that metformin can improve body mass index (BMI) and reduce waist circumference in women with type 2 diabetes. These results suggest that metformin may also be helpful for women experiencing weight gain and changes in body composition during menopause.

However, it is important to note that weight loss is not one of the primary purposes of prescribing metformin for menopause symptoms. If weight loss is a goal, dietary changes and exercise should be prioritized.

Also, although metformin may help reduce abdominal fat, it may not reduce overall body weight significantly.

3. Impact on Hot Flashes

Hot flashes are one of the most common symptoms of menopause and can have a significant impact on quality of life. Some studies have suggested that metformin may reduce the frequency and severity of hot flashes.

In a study of postmenopausal women with type 2 diabetes, those who took metformin had fewer and less severe hot flashes compared to those who did not take the medication. However, more research is needed to confirm these findings and determine whether metformin would have similar effects in women without diabetes.

It is also important to note that metformin is not an FDA-approved treatment for hot flashes, and there are other treatments available that may be more effective in reducing hot flashes, such as hormone replacement therapy.

4. Possible Side Effects

As with any medication, metformin has potential side effects, although they are generally mild. Common side effects include gastrointestinal symptoms such as nausea, diarrhea, and stomach discomfort. These symptoms usually improve over time and may be minimized by taking the medication with food.

More serious side effects are rare but can include lactic acidosis, a potentially life-threatening condition in which there is an excess of lactic acid in the blood. This risk is higher in people with kidney or liver problems or in those taking certain medications. Additionally, vitamin B12 deficiency has been reported with long-term use of metformin.

Consulting with a healthcare provider before starting metformin is important to assess individual risks and benefits of the medication.

5. The Role of Metformin in Menopause Treatment

The use of metformin to treat menopause symptoms is a relatively new concept, and more research is needed to fully understand its potential benefits and risks.

While some studies suggest that metformin may be effective in reducing certain symptoms, it is not a substitute for more established treatments such as hormone replacement therapy. Additionally, it is important to note that metformin is primarily used to treat diabetes, and it should only be used for menopause symptoms under the guidance of a healthcare provider.

Overall, metformin holds promise as a possible treatment for some symptoms of menopause, particularly in women who also have type 2 diabetes. However, additional research is needed to determine how metformin can best be used to help women manage the physical and emotional changes associated with menopause.


Metformin may have potential benefits in alleviating symptoms of menopause, such as hot flashes and changes in weight and body composition, by affecting glucose metabolism and hormones. However, as with any medication, there are possible side effects and limitations to its use. Consulting with a healthcare provider to assess individual risks and benefits is important before starting metformin for menopause symptoms. Additionally, metformin is not a substitute for established treatments for menopause symptoms and should be used under the guidance of a healthcare provider.

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